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Hu, Yu Polycystic Kidney Disease

ISBN: 978-1-138-60389-9

Edition: 1st Ed.

Publication date: November 2019

Cover: Hardcover

Pages: 360 p.

Illustrations: 50 ill.

Publisher: CRC Press

Delivery times, dependent on availability and publisher: between 2 and 14 days from when you complete the order.

Description

This volume focuses on the investigatory methods applied to autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. ADPKD is caused by mutations in PKD1 and TRPP2, two integral membrane proteins that function as receptor/ion channels in primary cilia of tubular epithelial cells. Thus, ADPKD belongs to ciliopathies, a group of disorders caused by abnormal cilia formation or function. This proposed book will cover the state-of-the-art methods ranging from molecular biology, biochemistry, electrophysiology, to tools in model animal studies.

  • Explores the role of cilia in polycystic kidney disease
  • Focuses on myriad state-of-the-art methods and techniques
  • Reviews specific mutations integral to this autosomal genetic disease
  • Includes discussions of model systems