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Boorman’s Pathology of the Rat: Reference and Atlas, Third Edition, continues its history as the most comprehensive pathology reference on rat strains for researchers across science and medicine using rat models in the laboratory. It offers readers an added emphasis on the Sprague-Dawley and Wistar rat strains that is consistent with current research across academia, government, and industry.
In addition, the book provides standard diagnostic criteria, basic content on histology, histological changes that result from drug toxicity and neoplasm, pathology terminology, and four-color photographs from the NTP archive and database. With updated references and photographs, as well as coverage of all rat strains, this book is not only the standard in the field, but also an invaluable resource for toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to the promulgation of meaningful regulations.
The new edition includes topics not covered previously with contributors who at the forefront of each specific topic.
This book is the most comprehensive publication on rat pathology, now revised to include all rat strains and with an added emphasis on the Sprague-Dawley and Wister. It is an invaluable resource for toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to promulgation of meaningful regulations.
Chapters which were not significantly changed in the 2nd edition will be further updated by reference to the published literature
In all chapters the INHAND recommended diagnoses will be referenced where multiple terminology is described for individual lesions.
use of photomicrographs from the NTP archive, other archives and resources to which authors have access in order to make the photomicrograph atlas aspect of the book as extensive as possible.
chapters where there currently is limited description to normal histology of tissues, are expanded.
Since the rat is a major species for use in carcinogenicity testing, a chapter will be included on evaluation of tumor findings to assist readers in interpreting tumor data (including statistical analysis) and determining whether test compounds should be regarded as carcinogenic or otherwise
Examples of tumor profiles obtained from NTP studies and pharmaceuticals evaluated by the FDA are included to help the reader in understanding how tumor profiles are interpreted