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Ishigatsubo Behçet's Disease

From Genetics to Therapies

ISBN: 978-4-431-54486-9

Erscheinungsdatum: Dezember 2014

Einband: Hardcover

Seitenzahl: 176 p.

Illustrationen: 38 ill.

Verlag: Springer

Lieferzeit: 2 - 15 Tage

Beschreibung

  • Provides comprehensive information on Behçet´s disease
  • Covers the latest findings, including genetic studies and treatment
  • An essential resource for both basic researchers and clinical physicians​

This book, besides reviewing basic and clinical aspects of Behçet´s disease, covers the latest findings, including genetic studies and treatment with biologics for the disease.
Although the cause of Behçet´s disease is still unknown, it is well known that genetic factors, such as HLA-B51, are involved in its development. Recently, novel susceptibility loci including IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 have been identified, providing new insights into the pathogenesis of the disease. In addition to basic research, the beneficial efficacy of anti-TNF-alpha monoclonal antibodies has also been suggested for not only uveitis associated with the disease but also other subtypes of the disease such as entero-, vasculo-, and neuro- Behçet´s disease. Behçet´s Disease:  From Genetics to Therapies  provides essential information both for basic researchers working in the fields of immunology, inflammation, and genetics, and for clinical physicians who are interested in Behçet´s disease, such as ophthalmologists, rheumatologists, dermatologists, gastroenterologists, neurologists, and vascular surgeons.​